Effects of mFOLFOX7 neoadjuvant chemotherapy protocol on advanced gastric cancer
- VernacularTitle:奥沙利铂联合氟尿嘧啶、亚叶酸钙方案(mFOLFOX7)对进展期胃癌的疗效分析
- Author:
Lei CHEN
;
Hui-Zhong LIN
;
Xiang-Jun JIANG
;
Xiao-Chuan LI
;
Dong-Feng ZHOU
;
- Publication Type:Journal Article
- Keywords:
Advanced gastric cancer?Neoadjuvant chemotherapy?mFOLFOX7
- From:
Chinese Journal of Current Advances in General Surgery
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effect of mFOLFOX7 protocolon advanced gastric cancer. Methods: Forty-eight patients with advanced gastric cancer were randomly divided into two groups: conventional treatment group (24 cases, surgery-adjuvant chemotherapy)and synthesized treatment group (24 cases, mFOLFOX7 neoadjuvant chemotherapy-surgery-adjuvant). The effect and toxic reaction of mFOLFOX7 on the patients with advanced gastric cancer were observed, and the R0 resection rate, complications incidence, survival rate were compared between two groups. Results: In synthesized treatment group, total effective rate was 58.3% . Fourteen patients (58.3%)achieved R0resection in synthesized group were compared with 7 patients (29.2%)achieved R0 resection in conventional group (P0.05).Conclusion: mFOLFOX7 neoadjuvant chemotherapy protocol is low toxic reaction. It can improve R0 resection rate of advanced gastric cancer, complications correlated with surgery are not increased. But it can’t improve the survivalrate.
