Effects of Perinatal Exposure to Low-dose Tributyltin on Development and Estrogen Level of Female Offspring Mice
- VernacularTitle:围产期低剂量三丁基锡暴露对子代雌性小鼠发育及雌激素水平的影响
- Author:
Cheng-En WANG
;
Ji-Liang SI
;
Miao ZHANG
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Fertility;
Tributyltin;
Reproductive toxicity;
Estrogen
- From:
Journal of Environment and Health
2007;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of perinatal exposure to low dose tributyltin (TBT) on development and estrogen level of female offspring KM mice.Methods The CL healthy adult pregnant KM mice were randomly divided into 4 groups,6 in each group,they were given doses of TBT (100,10 and 1 ?g/kg) by gavage from days 6 of gestation to the end of lactation,1 time each day,at a volume of 1 ml/kg.On postnatal day (PND) 49,10 female offspring mice were randomly selected in each group and killed after weighed and the blood was collected.The uterus and ovary were weighed for account of viscera coefficient.The concentrations of estrogen in serum were measured with radioimmunoassay.Results Compared with the control group the time of eye opening was significantly delayed and the vagina opening was significantly ahead in treatment groups (P0.05).The weight of ovary and its coefficient increased significantly in 10 ?g/kg group (P
