Effect of bone marrow cell on chemotaxis of aggregation of macropahges in venous thrombosis
- VernacularTitle:骨髓细胞动员对巨噬细胞聚集静脉血栓趋化作用的影响
- Author:
Hao SUN
;
Yikuan CHEN
;
- Publication Type:Journal Article
- Keywords:
Bone marrow cell?Chemotactic factors?Macrophage
- From:
Chinese Journal of Current Advances in General Surgery
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the effect of bone marrow on chemotaxis of aggregation of macrophages in venous thrombosis.Methods:SD adult rats were divided randomly into normal group,sham operation group,thrombus group and rhG-CSF group.Peripheral blood was harvested at 30min before operation and on the 7th and 14th day after operation.Level of MCP-3 in peripheral blood was detected with ELISA.Inferior vena cava specimens of thromus group and rhG-CSF group were collected at postoperative 7th and 14th day.With the application of RT-PCR,expression of MCP-3mRNA in thrombus was detected.Results:The level of MCP-3 in peripheral blood of rhG-CSF group was significantly higher than that before operation and also higher than the levels of MCP-3 in peripheral blood of sham operation group and thrombus group on the 14th day after operation,(P
