Detection of mutations of exons 5 and exons 8 of PTEN gene in oral squamous cell carcinoma
- VernacularTitle:口腔鳞状细胞癌组织中PTEN基因第5、8外显子突变的检测
- Author:
Weiyan CHEN
;
Li GONG
;
Tiejun ZHOU
;
Xian′Gang YIN
;
- Publication Type:Journal Article
- Keywords:
OSCC;
Gene;
PTEN;
Mutation
- From:
Journal of Practical Stomatology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect mutations of exons 5 and exons 8 of PTEN gene in oral squamous cell carcinoma(OSCC),and to explore the relationship between gene mutations and development of OSCC.Methods: Mutations of exons 5 and exons 8 of PTEN gene were detected by polymerase chain reaction-single strand conformation polymorphism(PCR-SSCP).Results: The whole sequences of exons 5 and exons 8 of PTEN gene of all cases of OSCC were expanded.There was no mutation in exons 5 and exons 8 of PTEN gene of all cases of OSCC.Conclusion: There is no mutation in exon 5 and exon 8 of PTEN gene in OSCC.This might show that there is no correlation between mutations in exon 5 and exon 8 of PTEN gene and the development of OSCC.
