The analysis of the relationship between the clinical effect,pathological changes and the neoadjuvant chemotherapy containing THP and docetaxel on breast cancer
- VernacularTitle:乳腺癌多西他赛联合吡柔比星新辅助化疗与临床疗效及病理相关性分析
- Author:
Hong-Zhen QIN
;
Xi-Ru LI
;
Yan-Jun ZHANG
;
Yi-Qiong ZHENG
;
Rong LI
;
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
neoadjuvant chemotherapy;
estrogen receptor;
progesterone receptor;
CerbB-2
- From:
China Oncology
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:Neoadjuvant chemotherapy is one of the hot studied area in breast cancer research.Our aim was to explore the relationship between the clinical effect,pathological changes and the neoadjuvant chemotherapy containing THP and docetaxel on breast cancer.Methods:The expression of ER, PR and CerbB-2 in breast cancer tissue of patients who had received neoadjuvant chemotherapy were detected by immunohistochemistry method.The relationship of age,ER,PR,CerbB-2,pathological stage and axillary lymph node metastasis with pathological complete response(pCR) was analysed.Results:For the patients after neoadjuvant chemotherapy,the pCR of the positive ER(0%),PR(9.38%) was lower than that of negative ER(20.27),PR(90.63%) respectively.The pCR of the positive CerbB-2(33.33%) was higher than that of negative CerbB-2(9.74%,P
