Advances in research on relationship between Hedgehog signal pathway and gastroenteric tumor
- VernacularTitle:Hedgehog信号通路与胃肠道肿瘤的相关性研究进展
- Author:
Lei DAI
;
Ji-Kun LI
;
- Publication Type:Journal Article
- Keywords:
gastric cancer;
colorectal cancer;
Hedgehog;
Wnt;
TGF-?
- From:
China Oncology
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Hedgehog(HH),a vital endodermal signal,plays a critical role in the embryonic development of the GI system.During mammalian embryonic development,deficiency of HH signaling leads to gastrointestinal malformations.Nevertheless,normal presence of HH family is also found in the adult gut,and HH signaling now may be important for homeostasis of the gut in such a case.However,many researches revealed that the HH signal's involved in gastrointestinal carcinogenesis and its role is altered in various tumors due to various mechanisms.This review focused on the progress of HH signal pathway in gastrointestinal tumors.
