Her-2/neu gene and radiosensitivity
- VernacularTitle:Her-2/neu基因与放射敏感性
- Author:
Jiong-Yan LI
;
Xiao-Mao GUO
;
- Publication Type:Journal Article
- Keywords:
Her-2/neu;
anti-Her-2 antibody;
radiotherapy;
malignant tumors
- From:
China Oncology
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Her-2 receptor has already been identified as one of the most important biological markers of some malignant tumors,and also plays an important role in the biological behavior of those tumor cells.The over-expression of Her-2 receptor is associated with radioresistance of various tumor cells,and thus an antibody to Her-2/neu receptor can probably function as a radiosensitizer.In this review,we summarized some advances in the molecular mechanism and clinical aspects of the relationship between Her-2 and cellular radiosensitivity.
