Thyroid Hormone Disrupting Activities of Tetrabromobisphenol-A:a Review
- VernacularTitle:四溴双酚-A的甲状腺激素干扰活性研究进展
- Author:
Ma-Li CHEN
;
Qing-Po LIU
;
Hua-Hong SHI
;
- Publication Type:Journal Article
- Keywords:
Endocrine disrupting chemicals;
Thyroid disrupting activities;
Brominated flame retardants;
Tetrabromobisphenol-A
- From:
Journal of Environment and Health
2007;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Tetrabromobisphenol A(TBBPA)is supposed to have potential thyroid disrupting activities due to its similar structure to thyroid hormones.TBBPA has been proved to show thyroid disrupting effects in vivo and in vitro studies.TBBPA might disrupt thyroid hormone system through transthyretin- and thyroid receptor-mediated pathways.The ability of TBBPA inducing the production of reactive oxygen species might be the extension of its thyroid disrupting activities.The thyroid disrupting effects of TBBPA might be closely related to its oxidative stress,reproduction toxicity and neurotoxicity.More experiments are required for the effects of TBBPA on the aquatic and amphibian animals.
