Pulmonary Toxicity of Three Typical Nanomaterials Caused by Intratracheal Instillation in Rats
- VernacularTitle:三种典型纳米材料非暴露式气管滴注染毒对大鼠肺的毒性效应
- Author:
Li MA
;
Zhu-Ge XI
;
Ying-Ge ZHANG
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Nano-feroso-ferric oxide;
Nano-silicon dioxide;
Single walled carbon nanotube;
Oxidative damage
- From:
Journal of Environment and Health
2007;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the toxic effect of nona-ferroso-ferric oxide(Nano-Fe_3O_4),nano-silicon dioxide(Nano- SiO_2)and single walled carbon nanotubes(SWCNTs)on the lung and mechanism in rats.Methods Fourty-nine Wistar rats were randomly divided into 7 groups,the control group,low and high dose groups of three nanomaterials.The rats were exposed by intratracheal instillation once two days for 5 weeks,and then killed by abdominal aorta bloodletting.The pathology of lung,lactate dehydrogenase(LDH),total antioxidant capacity(T-AOC),superoxide dismutase(SOD),malondialdehyde(MDA),interleukin-1(IL- l),interleukin-6(IL-6)and tumor necrosis factor-?(TNF-?)in bronchoalveolar lavage fluid(BALF)were determined.Results The fibrous tubercle and the matrix inflammation of lung tissue was found in the experimental groups.The activities of T-AOC and SOD decreased while IL-6 concentration increased significantly in the experimental groups(P
