Effect of Arsenic Exposure through Drinking Water on the Levels of Blood Arsenic and Brain Arsenic,Learning and Memory of Rats
- VernacularTitle:饮水砷暴露对大鼠血液和脑组织砷蓄积及学习与记忆能力的影响
- Author:
Jiao-Hua LUO
;
Zhi-Qun QIU
;
Yong-Yan ZHANG
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Arsenic;
Morris water maze;
Learning and memory ability;
Blood arsenic;
Brain arsenic
- From:
Journal of Environment and Health
2007;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of arsenic exposure on learning and memory ability of rats.Methods Fourty- eight weaned SD rats were randomly divided into four groups,12 in each.The control group drank tap water,the other three groups treated with sodium arsenite at doses of 2.72 mg/L,13.6 mg/L and 68 mg/L for 12 weeks.Morris water maze was used to test the spatial learning and memory ability of rats.Arsenic level in the blood and brain was assessed after Morris water maze test.Results Arsenic contents in the blood of arsenic exposed rats were significantly higher than that in control rats(P
