Effect of Dimethyiformamide(DMF) on Histological Structure and Enzymes Activity in Testis of Mice
- VernacularTitle:二甲基甲酰胺对小鼠睾丸组织结构和睾丸酶的影响
- Author:
Yun-He ZHENG
;
Lu HUANG
;
Xu-Jian HOU
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Dimethylformamide;
Testis;
Pathology;
Testis enzyme
- From:
Journal of Environment and Health
2007;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of dimethylformamide(DMF)on the histological structure and enzymes activity in the testis of mice.Methods The KM male mice were treated with DMF by gavage at the doses of 0,0.5,1 and 2 g/kg respectively, once a day,for 30 consecutive days.On day 31,the mice blood samples were collected through eyes and then the mice were killed. Two mice were randomly selected in each group and one testicle was sampled to do the pathological examination,the other one for enzyme activity determination,including succinic acid dehydrogenase(SDH),lactate dehydrogenase(LDH)and acid phosphatase (ACP).Results Compared with the control group,all treated groups showed a significant decrease in body weight(P
