Effects of Nitrobenzene on Immunity Function of Mice
- VernacularTitle:硝基苯对小鼠巨噬细胞毒功能及淋巴细胞转化功能的影响
- Author:
Jing-Shun LI
;
Rui WANG
;
Lian-Sheng SONG
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Environmental pollutants;
Nitrobenzene;
Immunity function;
Lymphocyte proliferation;
Macrophage function
- From:
Journal of Environment and Health
2007;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of nitrobenzene on macrophage function and lymphocyte proliferation in mice. Methods ICR mice were divided into groups and treated with nitrobenzene by gavage,once a day,at doses of 2,20 and 200 mg/kg respectively,for 21 consecutive days.The mice were killed after 21 days of treatment and then the effects of nitrobenzene on the organs index,the maerophage function and the lymphocyte proliferation were determined.Results The maerophage function and the lymphocyte proliferation decreased as the increase of the dose of nitrobenzene.Conclusion The results of the present paper show that nitrobenzene may inhibit the immunity function of mice.
