Antagonistic Effect of N-acetyI-L-cysteine and ?-Lipoic Acid to Oxidative Damage in Liver and Kidneys of Rats Induced by Condensate of Cooking Oil Fume
- VernacularTitle:N-乙酰半胱氨酸和?-硫辛酸对烹饪油烟凝集物氧化损伤的拮抗作用
- Author:
Chuan-Long ZONG
;
Bai-Yun ZHOU
;
- Publication Type:Journal Article
- Keywords:
Air pollution,indoor;
Condensate of cooking oil fume;
N-acetyl-L-cysteine;
?-lipoic acid
- From:
Journal of Environment and Health
2007;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the antagonistic effect of N-acetyl-L-cysteine(NAC)and ?-lipoic acid(LA)to the oxidative damage in the liver and kidney of rats induced by the condensate of cooking oil fume(COF).Methods SD rats were randomly divided into 4 groups,8 in each,the blank control,COF group(10 ml/kg,subcutaneous injection),COF plus NAC(2 mmol/kg, intraperitoneal injection)and COF plus LA(0.35 mmol/kg,intraperitoneal injection).Forty-eight hours after treatment,the activity of SOD,GSH-Px and MDA level in the livers and kidneys were determined.Results In the kidney,compared with the COF group, both of NAC and LA could increase the activity of kidney SOD and GSH-Px and decreased the MDA level significantly,the same results were seen in the liver.Conclusion Both of N-aeetyl-L-cysteine and ?-lipoic acid has an obvious antagonistic effect to the oxidative damage in the liver and kidney of rats induced by the condensates of cooking oil fume.
