The Anti-oxidation Activity and Liver Damage Induced by Chronic Fluorosis in Male Rats
- VernacularTitle:慢性氟中毒对雄性大鼠肝脏的损伤及其抗氧化能力的影响
- Author:
Shu-Jun CHEN
;
Yu-Min SUN
;
Yu-Jun MENG
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Fluorosis;
Nitric oxide;
Nitric oxide synthase;
Liver
- From:
Journal of Environment and Health
2007;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To know the relationship between the changes of total anti-oxidation capacity (T-AOC),nitric oxide (NO) and nitric oxide synthase (NOS) the liver and liver damage induced by chronic fluoride exposure.Methods Eighteen male Wistar rats were randomly divided into 3 groups,control(treated with tap water),low fluoride(LF,treated with NaF at 100 mg/L) and high fluoride (HF,treated with NaF at 200 mg/L),6 in each group.Fluoride was given through drinking water.During the period of exposure,the body was weighed and after 6 months of treatment,the rats were killed,the liver coefficient was calculated,T-AOC, NO and NOS in the livers were determined respectively.Results Compared with the control,the liver coefficient,NO and NOS in the fluoride treated groups significantly increased (P
