Expression and correlation of p27 and survivin in NSCLC
- VernacularTitle:p27、生存素在非小细胞肺癌中的表达及相关性
- Author:
Xiang-Dong LI
;
Ju WANG
;
Run-Sheng WEI
;
- Publication Type:Journal Article
- Keywords:
non-small cell tung cancer;
p27;
survivin;
immunohistochemistry
- From:
China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:Tumor is a disease associated with multi-gene mutation and the abnormal expression of multi-gene expression in many steps through the process of the evolution of cell clone.A lot of oncogenes and anti-oncogenes like p27,survivin,etc.take part in the regulation of the cell cycle directly or indirectly. We studied the expression and correlation of p27 and survivin in NSCLC.Methods:The expression of p27 and survivin was detected in 60 NSCLC and 20 normal pulmonary tissues by the immohistochemical staining.Results: (1)P27 expression in NSCLC was 40.0%,significantly lower than normal pulmonary tissues(P
