Expressions of MG7 in tissue and serum in cancerization risk prediction of gastric precancerosis and its clinical significance
- VernacularTitle:血清与组织中MG7抗原表达对胃癌前病变风险预测的临床意义
- Author:
Jin WU
;
Hua-Xing WU
;
Dan LIU
;
Bei-Li LI
;
Ning ZHAO
;
Ying-Jun LI
;
Guo-Nian WANG
;
- Publication Type:Journal Article
- Keywords:
gastric cancer associated antigen MG7;
gastric cancer;
gastric precancerosis
- From:
China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:Through detection of MG7-Ag expression in various types of gastric mucosa biopsy tissues as well as serum,we studied their correlation and its clinical application value in the role of prediction of gastric precancerosis and its clinical significance.Methods:Using 125 samples of gastric mucosa biopsy tissues and corresponding sera(12 samples of normal gastric mucosa,21 samples of superficial gastritis,24 samples of gastric mucosal erosion and ulcer,15 samples of atrophic gastritis,22 samples of dysplasia,31 samples of gastric cancer)MG7-Ag expression in tissues was detected by SP immunohistochemical two-step staining;enzyme-linked immunosorbent assay was used to detect serum content of antigen MG7.Results:No expression of MG7 was detected in 12 samples of normal gastric mucosa and the positive expression rate of MGT-Ag was 93.55% in 31 samples of gastric cancer.In the order of superficial gastritis,gastric mucosal erosion,ulcer,atrophic gastritis,dysplasia and gastric cancer,expression rate of MG7 was increased sequentially(P
