Expression of chemokine receptor CXCR4 in hypopharyngeal carcinoma and its significance
- VernacularTitle:趋化因子受体CXCR4在下咽鳞癌组织中的表达及其意义
- Author:
Guo-Hua SUN
;
Yong-Xue ZHU
;
Cai-Ping HUANG
;
Yu WANG
;
Ling ZHANG
;
Xue-Chen WANG
;
Qing-Hai JI
;
- Publication Type:Journal Article
- Keywords:
hypopharyngeal neoplasm;
squamous cell carcinoma;
CXC chemokine receptor 4;
immunohistochemistry
- From:China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:It was reported that chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1(SDF-1)were involved in the proliferation,differentiation,and metastasis of tumor.This study was designed to observe the expression of chemokine receptor CXCR4 in hypopharyngeal squamous cell carcinoma tissue and study the relationship between the expression of chemokine receptor CXCR4 and different clinicopathlogical characteristics,and further to explore the clinical significance.Methods:For the detection of the expression of chemokine receptor CXCR4,43 primary hypopharyngeal squamous cell carcinoma tissues,27 normal hypopharyngeal tissues,34 lymph node metastastatic lesions and 9 normal lymph node lesions were detected by immunohistochemical method using rabbit anti-human CXCR4 polyclonal antibody.Results:The positive expression rates of CXCR4 in 43 hypopharyngeal carcinoma tissues and normal tissues were 95.3% and 22.2%,respectively(P
