Relationship between survivin expression and paclitaxel drug-resistance and research of reversed drug-resistance by matrine in non-small cell lung cancer
- VernacularTitle:非小细胞肺癌survivin表达与紫杉醇耐药的关系及苦参碱逆转耐药的研究
- Author:
Su-Xia LUO
;
Xiao-Bing CHEN
;
Ning LI
;
Jun-Jie ZENG
;
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small cell lung;
Inhibitor of apoptosis proteins;
Drug resistance,neoplasm;
Paclitaxel;
Matrine
- From:
Cancer Research and Clinic
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between drug-resistance of paclitaxel and the expres- sion levels of anti-apoptotic protein survivin and the role of matrine reversal resistance of PTX in non-small cell lung cancer.Methods The expressions of survivin in 120 samples of human lung cancer with paclitaxel chemotherapy were detected by immunohistochemical staining.Results The positive expression rate of sur- vivin was 57.5%.In the positive expression of survivin group,chemotherapy combined matrine could improve response rate and survival time(P0.05).Conclusion The survivin expression was related to the response rate of paclitaxel in lung cancer.It might be a valuable new marker to predict the drug-resistance of paclitaxel.In this prospective research,survivin protein,which promoted the apoptosis caused by paclitaxel,may be the target of martine.It could partly reverse the drug re- sistance to paclitaxel.
