Roles of TPX2 in cell mitotic and the relation with tumorigenesis
- VernacularTitle:TPX2在细胞有丝分裂中的作用及与肿瘤发生的关系
- Author:
Yun-Xiang ZHANG
;
Xiang-Zhou LI
;
- Publication Type:Journal Article
- Keywords:
Microtubule-associated proteins;
Mitosis;
TPX2;
Neoplasms
- From:
Cancer Research and Clinic
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
TPX2(targeting protein for Xklp2)is a microtubule-associated protein in a new family of vertebrate spindle pole components.TPX2 is diffusely distributed all over the nucleus during the cell cycle phases S and G_2 and play important roles in mitotic spindle formation.TPX2 over expression was found in a variety of malignant tumors,that are asssociated with the centrosome amplification,aneuploidy,cell transfor- mation and the biological behavior of tumor.Blocking the expression of TPX2 can inhibit the growth of tumor cells.TPX2 may serve as a new candidate target for tumor therapy.The study progress of its structure and function,expression levels in cell cycle,molecular mechanism etc.was reviewed.
