Effects of different levels of iodine nutrition on liver typeⅠdeiodinase and brain typeⅡdeiodinase activities in rat
- VernacularTitle:不同碘营养状态对大鼠肝组织Ⅰ型脱碘酶和脑组织Ⅱ型脱碘酶活性的影响
- Author:
Bei SUN
;
Ai-Jun ZUO
;
Dong-Chun LIANG
;
Gang GUO
;
Xue-Qin ZHAO
;
Yu-Qin YAN
;
Zu-Pei CHEN
;
Jing-Yu ZHANG
;
- Publication Type:Journal Article
- Keywords:
Iodide peroxidase;
Iodine deficiency;
Iodine excess
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Wistar rats with different levels of iodine nutrition were killed after 3,6 and 12 months of experiments.Serum thyroid hormones were assayed with RIA.The activity of typeⅠdeiodinase(DⅠ)and typeⅡdeiodinase(DⅡ)was measured based on the release of radioiodide from the ~(125)Ⅰ-labeled substrate.The result showed that hypothyroidism reflected by decreased T_4 happened during the initial phase of iodine deficiency.The activity of DⅠand DⅡin rats was raised significantly in iodine deficiency groups.An excess of iodine inhibited DⅠactivity resulting in decreased serum TT_3 and FT_3.However,DⅡactivity increased in rats with iodine excess, attributing to the inactivation of T_3 and T_4 to the substrate of DⅡenzyme.
