Effect of adult-onset hypothyroidism on neurogranin expression in hippocampus of adult male mice
- VernacularTitle:成年期甲状腺功能减退对雄性小鼠海马神经颗粒素表达的影响
- Author:
Xian-Zhong ZENG
;
De-Fa ZHU
;
Gui-Hai CHEN
;
Wei-Qing MA
;
- Publication Type:Journal Article
- Keywords:
Hypothyroidism;
Neurogranin;
Adult;
Mice
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Adult male Kunming mice were divided into normal control group,propylthiouracil(PTU) treated group and PTU+T_4 treated group.Neurogranin(Ng)protein expression in the hippocampus after 8 weeks was assayed by Western blotting and immunohistochemical method.Results showed that Ng protein was decreased in the hippocampus of male mice with adult-onset hypothyroidism,suggesting that decreased Ng,which is correctable by T_4,is involved in cognitive dysfunction in adult-onset hypothyroid male mice.
