High-dose dexamethasone suppression test-related differences in the clinical and biochemical features of Cushing's disease
- VernacularTitle:大剂量地塞米松抑制试验不可抑制的库欣病患者临床和生化特点分析
- Author:
Huali QIE
;
Zhao-Hui JIAN
;
Guo-Qing YANG
;
Jing-Tao DOU
;
Yi-Ming MU
;
Ju-Ming LU
;
Chang-Yu PAN
;
- Publication Type:Journal Article
- Keywords:
Cushing syndrome;
High-dose dexamethasone suppression test;
Adrenocorticotrophic hormone;
Cortisol
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the high-dose dexamethasone suppression test(HDDST)-related differences in the clinical and biochemical features of the patients with Cushing's disease Methods Cases were drawn from 60 consecutive patients with Cushing's disease,who were then divided into two groups according to the response to the HDDST.The clinical and biochemical features between two groups were compared.Results(1) Of the 60 patients with Cushing's disease,23.3%(14/60)of patients(group A)did not yield results of suppression with the HDDST,and the others(group B)did.No difference was found in the age[(33.8?10.4 vs 36.2?11.2)years]and duration of illness[(2.1?1.6 vs 3.9?3.1)years]between two groups.(2)In clinical features,the patients in group A were more likely to have edema of lower limbs(64.3% vs 32.6%),hypokalemia (71.4% vs 28.3%),secondary diabetes(57.1% vs 26.1%)and purple striae(85.7% vs 54.3%,all P
