Effect of 1-deoxynojirimycin on high glucose-stimulating proliferation of rat mesangial cells
- VernacularTitle:1-脱氧野尻霉素对高糖刺激大鼠系膜细胞增殖的影响
- Author:
Ai-Hong YUAN
;
Jun MA
;
Xiang-Cheng XIE
;
Jie-Li HUANG
;
Xiao-Feng JIANG
;
Xiu-Zhen ZHANG
;
- Publication Type:Journal Article
- Keywords:
1-deoxynojirimycin;
Proliferation;
Integrin?1;
?-smooth muscle actin;
Mesangial cells
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of 1-deoxynojirimycin(DNJ)on the proliferation of rat mesangial cells was observed and its mechanism was explored.The results showed that DNJ significantly inhibited the proliferation of rat mesangial cells induced by high glucose in time-and dose-dependent manners.DNJ significantly decreased expressions of?-smooth muscle action(?-SMA),integrin?1 mRNA and protein and focal adhesion kinase (FAK)protein stimulated by high glucose in rat mesangial cells(P
