Experimental study on participation of interstitial cells of Cajal and connexin 43 in the pathogenesis of diabetic gastroparesis
- VernacularTitle:Cajal间质细胞和间隙连接蛋白43参与糖尿病胃轻瘫机制的实验研究
- Author:
Han-Ni WU
;
Han TIAN
;
Xi-Ting ZHANG
;
Wei QIAN
;
Jing-Song LIU
;
Xiao-Hua HOU
;
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
experimental;
Gastroparesis;
Interstitial cells of Cajal;
Gap junction;
Connexin 43
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The changes of interstitial cells of Cajal(ICC)distribution and connexin 43(Cx43)expression in gastric muscle layers were assayed in gastroparesis models of streptozotocin-induced diabetic rats.The results showed that gastric emptying was significantly delayed,the contraction frequency and amplitude of gastric muscle segments were greatly decreased,Cx43 gray values were significantly increased and Cx43 distributed homogeneously with ICC immunopositivity in the model rats.These changes appear to be related to the pathogenesis of diabetic gastroparesis.
