Effect of thyroid morphologic change and initiating treatment time on mental development in children with congenital hypothyroidism
- VernacularTitle:先天性甲状腺功能减退症患儿甲状腺形态学改变和治疗时机对智力发育的影响
- Author:
Qun JIANG
;
Lian-Shu HAN
;
Jun YE
;
Xue-Fan GU
;
- Publication Type:Journal Article
- Keywords:
Hypothyroidism;
congenital;
Treatment time;
Thyroid hormones;
Mental development
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of the thyroid morphologic change,the initiating treatment time and the thyroid function(serum FT_4,TSH)on mental development in children with congenital hypothyroidism (CH).Methods After diagnosed,52 cases of CH were orally administrated with L-T_4,then their mental and physical development were monitored and thyroid morphologic changes were observed by thyroid imaging(~(99m)TcO_4) and type B ultrasonography.The Bayley test was performed at the age of 10 to 30 months and expressed as mental developmental index(MDI)and psychomotor developmental index(PDI).Analysis was conducted upon treatment timing and thyroid morphologic changes.Results The MDI in those cases with morphologic abnormalities treated within 90 days was significantly lower than that with normal morphology(91?20 vs 105?15,P
