Effects of all-trans retinoic acid on proliferation,iodide uptake and thyroid specific gene expression in different cell lines of human thyroid carcinoma
- VernacularTitle:全反式维甲酸对各种人甲状腺肿瘤细胞株增殖、摄碘及甲状腺特异基因表达的影响
- Author:
Dai CUI
;
Ling LAN
;
Chao LIU
;
Lin JIANG
;
Wei TANG
;
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Tretinoin;
Proliferation;
Iodide uptake;
Receptor;
retinoid acid
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Different human thyroid carcinoma cell lines were treated with all-trans retinoic acid(RA). RA could inhibit cell growth,improve iodide uptake and increase some thyroid specific genes and retinoid acid receptor(RAR)mRNA expressions in FTC-133 cells.However,RA had no effect in C643,HTH74 and XTC. UC1 cells.These findings indicate that different thyroid carcinoma cells display diverse responses to RA.
