Gene Gly82Ser polymorphism of receptor of advanced glycaton end products in patients with transient ischemia attack
- VernacularTitle:短暂性脑缺血发作与晚期糖基化终末产物受体基因Gly82Ser多态的关联
- Author:
Hai-Ping WANG
;
Ren-Liang ZHAO
;
Xiao-Jin SONG
;
Chen ZHANG
;
Ji-Jun TENG
;
Yu-Qiang SONG
;
- Publication Type:Journal Article
- Keywords:
Ischemia attack,transient;
Diabetes mellitusvReceptors,immunologic;
Polymorphism,restriction fragment length
- From:
Chinese Journal of Neurology
2005;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between receptor of advanced glycaton end products(RAGE)gene Gly82Ser polymorphism and patients with transient ischemia attack(TIA).Methods The Gly82Ser gene at the position of RAGE gene exon 3 was identified by a polymerase chain reaction- restriction fragment length polymorphism(PCR-RFLP)method in 70 cases of TIA & Diabetes(DM), 60 of simply TIA and 66 healthy control subjects.Results The genotypes of RAGE gene Gly82Ser identified were GG, GS and SS.The frequencies of RAGE gene Gly82Ser GS heterozygous genotype of TIA & DM and control were respectively 62.9% and 43.9%, significantly higher in TIA & DM patients than in control subjects(OR 2.036, 95% CI 1.021--4.062, P=0.042), however no significant difference was found between simply TIA and control(53.3% vs 43.9%, OR 1.299,95% CI O.644--2.618, P=0.465). Significant difference of the frequency of S allele was found neither between TIA & control and control(being 34.3% and 26.5%, respectively, OR 1.446,95% CI 0.859--2.434, P=0.164), nor between simple TIA and control(28.3% vs 26.5%, OR 1.096,95%CI 0.630--1.907, P=0.746).Conclusions RAGE gene Gly82Ser GS heterozygous genotype may be associated with TIA & DM patients.RAGE gene Gly82Ser polymorphism is a risky factor for TIA & DM patients, but not for TIA patients.
