Effects of atorvastatin on experimental autoimmune encephalomyelitis
- VernacularTitle:阿托伐他汀对实验性自身免疫性脑脊髓炎的治疗作用
- Author:
Li GUO
;
Jing YANG
;
Ya-Fei SUN
;
Xiu-Juan SONG
;
- Publication Type:Journal Article
- Keywords:
Encephalomyelitis,experimental autoimmunevHeptanoic acids;
Pyrroles;
Interleukin-4;
Gelatinase B
- From:
Chinese Journal of Neurology
2005;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of atorvastatin on the experimental autoimmune encephalomyelitis(EAE)and the underlying mechanism of immunoregulation.Method The Wistar rats were used to establish EAE model.After oral administration of 2, 8 mg? kg~(1)?d~(1)of atorvastatin, the rats were examined for the development of neurological signs, changes of histopathology and the expression of IL-4 and MMP-9.Result Though high dose treatment with atorvastatin, the frequency of EAE attacks degreased from 76.67% to 33.33%(P=0.008);the extent of inflammation degreased from 3.2?1.1 to 1.3?0.4(P=0.01);and the number of MMP-9 positive cells degreased from 37?7 to 26?5(P= 0.001), the expression of IL-4 could be increased from(0.35?0.12)ng/ml to(0.68?0.23)ng/ml (P=0.05).Conclusion Atorvastatin can reduce the inflammation and produce the recover of the neurological harm because of the changes of MMP-9 and IL-4.
