Role of NF-?B in hepatocyte apoptosis induced by intestinal perforations due to abdominal firearm wound
- VernacularTitle:NF-?B在腹部火器伤肠管穿透后肝细胞凋亡中的作用
- Author:
Jiang-Wei LIU
;
Yong-Jiu ZHANG
;
Ze-Xin LI
;
Yue-Tao LV
;
Yong-Hua XU
;
Bing YAN
;
Tao LEI
;
- Publication Type:Journal Article
- Keywords:
Nuclear factor-?B?Abdominal injuries?Firearm wound ?Hepatocyte apoptosis?Liver injury
- From:
Chinese Journal of Current Advances in General Surgery
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the role of NF-?B in signal transduction of hepatocyte apoptosis in liver injury. Methods: A total of 42 Chang-Bai piglets were divided into 7 groups: control group, 1, 2, 4, 8, 12, and 24 hours wound group. The model of intestinal perforations due to abdominal firearm wound was established in wound groups. Hepatic NF-?B activity was measured with immunohistochemical staining and image analysis in all groups. Hepatocyte apoptosis indexes and serum ALT levels were also determined. Results: Levels of hepatic NF-?B activity in wounded groups were significantly elevated compared with control group, and there were two peaks (1 and 8 hours group P
