Study on the changes of coagulation and fibrinolysis system in solid cancer patients and the mecha-nism of venous thromboembolism and metastasis of solid cancer
- VernacularTitle:凝血和纤维蛋白溶解系统与实体瘤静脉血栓形成及转移的相关研究
- Author:
Zhao-Xia DUAN
;
Lin-Hua YANG
;
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Blood coagulation;
Fibrinolysis;
Venous thrombosis
- From:
Cancer Research and Clinic
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of coagulation and fibrinolysis systems in patients with solid cancer. Determine the mechanism of thrombosis formation in solid cancer and the the metastasis mechanism of solid cancer.Methods To measure plasma concentrations of TF,TFPI,t-PA,u-PA,PAI-1 by ELISA and test protein C activity(PC:A)by chromogenic substrate assay.Results Plasma concentrations of TF,TFPI,u-PA,PAI-1 were all higher in solid cancer patients than normal control and higher in metasta- sized team than non-metastasized team.In the dead team,u-PA and PAI-1 were higher while TFPI was low- er. t-PA was higher in cancer patients combined with venous thromboembolism while protein C activity was lower.Conclusion Disorders of coagulation and fibrinolysis system are related to the thrombosis formation in solid cancer.Coagulation and fibrinolysis factors take part in the metastasis progress of solid cancer. High concentration of u-PA and PAI-1 or low concentration of TFPI are considered to be related with poor outcome.
