Expressions of IL-1?,IL-6,SCF,TPO on bone marrow stromal cells in patients with multiple myelo-ma
- VernacularTitle:多发性骨髓瘤患者骨髓基质细胞IL-1?、IL-6、SCF、TPO表达的研究
- Author:
Wen-Yi SHEN
;
Hua LU
;
Xiao-Ming FEI
;
Peng LIU
;
Jian-Yong LI
;
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Bone marrow microenvironment;
Bone marrow stromal cells;
Cytokine;
RT-PCR
- From:
Cancer Research and Clinic
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study multiple cytokine mRNA expressions of bone marrow stromal cells in patients with multiple myeloma(MM),as well as to explore the role of these cytokines in the occurrence and development of MM.Methods Semi-quantitiative RT-PCR was used to detect the mRNA expressions of IL- 1?,IL-6,SCF,TPO.Results The mRNA expression levels of IL-1? and IL-6 were higher than that of nor- mal controls and other hematological malignancies(P
