A clinical study of recombinant human granulocyte colony-stimulating factor on prevention of leukopenia caused by chemotherapy
- VernacularTitle:化疗前应用重组人粒细胞集落刺激因子预防白细胞减少
- Author:
Ya-Bin SHI
;
Jing-Sheng HE
;
Xu-Mei SONG
;
Yun-Hua WANG
;
Xue-Hong ZHU
;
Yu-Guo ZHAO
;
Lei KOU
;
Qun-Xian LU
;
- Publication Type:Journal Article
- Keywords:
Antineoplastic combined chemotherapy protocols;
Granulocyte colony stimulating fac-tor,recombinant;
Leukopenia
- From:
Cancer Research and Clinic
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the preventive value of recombinant human granulocyte colony stimulating factor(rhG-CSF)in cancer patients after chemotherapy.Methods In the open study,enrolled 52 patients with previously untreated cancer and with normal bone marrow function were randomly divided into 2 matched groups,A and B group.Each patient received one cycle of chemotherapy.In the study cycle,the pa- tients received a single subcutaneous injection of rhG-CSF 150 ?g before 24 hours of chemotherapy and in control cycle the patients only received chemotherapy.Efficacy and safety parameters were monitored.Results The incidence rates of leukopenia in the 26 valuable study cycles and 26 valuable control cycles were 19.23 % and 53.85 %,There were significant lower than those of group B(P
