Neuroimaging features in mitochondrial encephalomyopathies with lactic acidosis and stroke-like episodes in 22 patients
- VernacularTitle:线粒体脑肌病伴高乳酸血症和卒中样发作22例神经影像学特点分析
- Author:
Jie LIN
;
Wen-Hua ZHU
;
Yin WANG
;
Jun HUANG
;
Chong-Bo ZHAO
;
Jian-Ying XI
;
Jia-Hong LU
;
- Publication Type:Journal Article
- Keywords:
MIELAS syndrome;
Magnetic resonance imaging;
Tomography,X-ray computed
- From:
Chinese Journal of Neurology
2005;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the neuroimaging features in mitochondrial encephalomyopatbies with lactic acidosis and stroke-like episodes(MELAS).Methods Twenty-two clinically diagnosed patients who came from department of neurology,Huashan hospital in October 2003 to July 2006 were analyzed for CT,MRI,MRI contrast,MRA and MRS.Results In all 22 patients,the neuroimaging results of 21 were positive.There were 9 patients lying in hemisphere,12 in both cerebral hemispheres,including occipital,parietal,temporal and frontal lobe.The abnormal areas showed low signal intensity on T_1-weighted MRI,high signal intensity on T_2-weighted MRI and fluid attenuated inversion recovery(FLAIR)images.The lesions of 12/16 patients on MR contrasted images were enhanced.The lesions of one patient showed malacoma-like changes,one showed Fahr syndrome' s change and another showed high signal intensity on MR contrasted images.Conclusion Although the neuroimaging features of MELAS are complicated,the specific ones could help to make the diagnosis.
