The role of hyperhomocystinemia in the oxidative stress and inflammation injury mechanism of ischemic injury in cerebral infarction
- VernacularTitle:高同型半胱氨酸血症在脑梗死氧化应激和炎症损伤机制中的作用
- Author:
Rong XUE
;
Dong-Mei WANG
;
Yan CHENG
;
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Hyperhomocystinemia;
Malondialdehyde;
Interleukin-8
- From:
Chinese Journal of Neurology
2005;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of cerebral infarction caused by hyperhomocystinemia.Methods A hundred and nineteen paitents with acute cerebral infarction were chosen for case group.According to their levels of plasm total homocystine,they were divided into two groups: hyperhomocystinemia group and nonhyperhomocystinemia group.Forty patents without cerebrovascular disease,hepatophy,nephrosis and thyroid gland disease were chosen as control subjects.Plasm levels of total homocystine,serum levels of MDA and IL-8 were measured respectively,their correlations were also studied.Results Plasma levels of tHcy(?mol/L)and serum levels of MDA(nmol/L)and IL-8 (ng/ml)showed a significant increase in case group(19.97,4.41?0.84,0.23?0.08)in comparison with control subjects(9.83,3.24?0.64,0.12?0.08),t values were 8.139,8.021,7.767 respectively(P
