Axonal lesion in chronic inflammatory demyelinating polyneuropathy
- VernacularTitle:慢性炎症性脱髓鞘性多神经病的轴索损害
- Author:
Xing-Hua LUAN
;
Yi-Min WANG
;
Ri-Liang ZHENG
;
Hong-Yan BI
;
Yun YUAN
;
- Publication Type:Journal Article
- Keywords:
Polyradiculoneuropathy;
chronic inflammatory demyelinating
- From:
Chinese Journal of Neurology
2005;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the axonal lesion in chronic inflammatory demyelinating polyneuropathy(CIDP).Methods Eighteen patients had undergone sural nerve biopsy.The clinical and electrophysiological distinction based on the different pathological changes were analyzed.Results Five patients with demyelination predominance which presented myelinated fiber with thin myelin.Three of them showed also mild axonal degeneration.Eight patients with axonal lesion predominance which presented Wallerian degeneration and regeneration of myelinated fibers.Three patients with mixed myelin and axon lesion of myelinated fibers and two with mild lesion.There was no significant difference between CIDP predominantly with axonal lesion and demyelination.Electrophysiological examination shows both axonal lesion and demyelination feature in some of the 2 types patients at the same time.Conclusions Axonal lesion is a common pathological change in CIDP and should not be considered as an exclusive criterion in diagnosis of the disease.Infiltration of macrophages is a common change.
