NF-kB expression in midbrain periaqueductal gray induced by electrical stimulation of dura near superior sagittal sinus in rats
- VernacularTitle:刺激大鼠上矢状窦区硬脑膜对中脑导水管周围灰质核因子-?B蛋白表达的影响
- Author:
Rong-Fei WANG
;
Sheng-Yuan YU
;
Ruo-Zhuo LIU
;
Lei JIANG
;
- Publication Type:Journal Article
- Keywords:
Migraine;
Dura mater;
NF-kappa B;
Periaqueductal gray;
Electric stimulation
- From:
Chinese Journal of Neurology
2005;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of nuclear factor-kappa B(NF-?B)protein in the nociceptive transmission of migraine attacks and NF-KB expression in the periaqueductal gray(PAG) induced by electrical stimulation of dura mater near the superior sagittal sinus(SSS)of the rats. Methods The rats were prepared by exposure of the superior sagittal sinus.The dura mater near the SSS was stimulated and NF-?B protein was detected in coronal brain sections using standard avidinbiotin immunohistochemistry.Results The number of NF-KB positive neurons in PAG expression increased to 111.7?15.7 in stimulation group,compared with 112.9?10.7 and 508.7?30.8 in blank group and sham-operated group respectively(t=-41.52 and t=-36.21,P
