Expression and significance of p53 and p21~(WAF1)proteins in hepatocellular carcinoma
- VernacularTitle:p53和p21~(WAF1)蛋白在肝细胞肝癌中表达的意义
- Author:
Chun-Yan GU
;
Jian-Guo YAO
;
Lei BAO
;
- Publication Type:Journal Article
- Keywords:
Protein p53;
Protien p21~(WAF1);
Liver neoplasms;
Immunohistochemistry
- From:
Cancer Research and Clinic
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and significance of p53 and p21_(WAF1)proteins in hep- atocellular carcinoma(HCC).Methods Immunohistochemical(S-P)method was used to detect the expression of p53 and p21~(WAF1)proteins in the 41 patients with HCC and 30 cases of paracancerous tissues.Results The positive rates of p53 and p21~(WAF1)proteins were 43.9 % and 75.6 % respectively.The expression of the proteins was significantly higher in tumor than that in corresponding paracancerous tissue(P0.05). p53 ex- pression showed significant difference in different pathologic grades and cases with or without intrahepatic metastasis and thrombus in the portal veins(P
