Relationship between islet autoantibodies and HLA-DQ genotypes in first-degree relatives of autoimmune type 1 diabetes
- VernacularTitle:1型糖尿病一级亲属胰岛自身抗体与HLA-DQ基因型的关系
- Author:
Jian-Ping WANG
;
Zhi-Guang ZHOU
;
Gan HUANG
;
Ying YUAN
;
Hai-Feng ZHOU
;
Can HOU
;
Ya-Ling YANG
;
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 1;
First-degree relatives;
HLA genotype;
Islet autoantibodies
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association of islet autoantibodies [ glutamic acid decarboxylase antibody(GADA),protein tyrosine phosphatase antibody(IA-2A)and insulin autoantibodies(IAA)1 with HLA- DQ genotypes in the first-degree relatives of autoimmune type 1 diabetes mellitus.Methods This was a cross- sectional and case-control study.Three hundred and fifty-one first-degree relatives with normal glucose tolerance of patients with type 1 diabetes mellitus and 376 healthy controls were recruited and measured for GADA,IA-2A and IAA by radioligand assay,and 156 first-degree relatives of patients with autoimmune type 1 diabetes mellitus and 278 controls were typed for genetic polymorphisms of HLA-DQ with PCR sequencing-based typing method.Results (1)DQA1*03,DQBI*0303,*0401 alleles and DQA1 * 03-DQBI * 0303,DQA1 * 05-DQBI * 0201,DQA1 * 03-DQBI * 0401 haplotypes were significantly increased in the first-degree relatives of autoimmune type 1 diabetes mellitus(P
