Effects of glucose and insulin on expression of scavenger receptor class B type Ⅰ in U937 macrophages
- VernacularTitle:葡萄糖及胰岛素对巨噬细胞清道夫受体BⅠ表达的影响
- Author:
Yang PENG
;
Jin ZHANG
;
Hui LI
;
Li LI
;
Xin MENG
;
Yan-Min YANG
;
Zuo-Dong PAN
;
Ping HE
;
- Publication Type:Journal Article
- Keywords:
Glucose;
Insulin;
Macrophages;
Scavenger receptor BⅠ
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
U937 macrophages were cultured with various concentrations of glucose and/or insulin for 24 h.Cell membrane scavenger receptor(SR)-BⅠprotein and mRNA were detected by Western blot and RT-PCR. The results showed that basal physiological insulin levels promoted SR-BⅠprotein expression of macrophages and high concentration of insulin significantly downregulated SR-BⅠ,but the transcription of SR-BⅠmRNA did not change.High glucose and high insulin accelerates atherosclerosis through synergetically downregulating SR-BⅠprotein expression,which may cause early onset and rapid progression of atherosclerosis in the patients with metabolic syndrome and type 2 diabetes mellitus.
