Effect of fluvastattn on extracelluar signal-regulated kinase activity in glomerular mesangial cells exposed to high glucose concentration
- VernacularTitle:氟伐他汀对高糖环境中肾小球系膜细胞胞外信号调节激酶活性的影响
- Author:
Ying LI
;
Hui-Jun DUAN
;
Tao ZHANG
;
Li-Hong ZHANG
;
Mao-Dong LIU
;
Xiu-Fen WANG
;
Qiong-Zhen LIN
;
- Publication Type:Journal Article
- Keywords:
Glomerular mesangial cells;
Extracellular signal-regulated kinase;
Fluvastatin
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
When the glomerular mesangial cells of rats were cultured in vitro at high glucose concentration,the activity of extraeellular signal-regulated kinase(ERK),the expression of transforming growth factor-?_1(TGF-?_1)mRNA and the content of typeⅣcollagen in the supematant were higher than those at normal glucose concentration.These effects were inhibited by fluvastatin.The results showed that the activation of ERK signal transduction pathways appeared to play a role in the onset and progression of diabetic nephropathy. Furthermore,fluvastatin could protect the kidney by inhibiting ERK signal transduction pathway and TGF-?_1 expression.
