Effects of benazepril on apoptosis and expression of Bax and Bcl-2 in kidney of diabetic rats with different blood glucose levels
- VernacularTitle:贝那普利对不同血糖状态糖尿病大鼠肾脏细胞凋亡及相关基因表达的影响
- Author:
Ke-Ke JIN
;
Yan-Hong LIN
;
Jing-Ye PAN
;
Wan-Tie WANG
;
Da-Wang WANG
;
Yi-Xiao XU
;
- Publication Type:Journal Article
- Keywords:
Angiotensin-converting enzyme inhibitors;
Diabetic nephropathies;
Blood glucose;
Apoptosis;
Rats,Sprague-Dawley
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic rats were induced by intraperitoneal injection of streptozotocin.TUNEL and immunohistochemistry results showed that the renal tubular cell apoptosis index(AI)and Bax protein expression were significantly reduced,and the Bcl-2 protein expression in glomeruli was significantly increased in diabetic rats with stable hyperglycemia treated by benazepril compared with diabetic rats with stable hyperglycemia treated by vehicle(all P
