Protective effect of antioxidative ?-lipoic acid on kidneys in type 2 diabetic rats
- VernacularTitle:抗氧化剂?-硫辛酸对2型糖尿病大鼠肾脏的保护作用
- Author:
Bo FENG
;
Xin-Feng YAN
;
Lei XU
;
Qiao-Hui QIAN
;
Hua WANG
;
Jun-Li XUE
;
- Publication Type:Journal Article
- Keywords:
Lipoic acid;
Diabetic nephropathies;
Oxidative stress
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
There were significant increase in urine protein excretion,raised malondialdehyde(MDA) level and expressions of NF-?B,p22phox and p47phox in renal tissue,and significant decrease in reduced glutathione,superoxide dismutase,vitamin C and E levels in type 2 diabetic Goto-Kakisaki rats after 12 weeks. There was obvious histomorphologic change in the kidneys.All the above indices were improved by intraperitoneal injection of?-lipoic acid(35 mg/kg q.o.d).Besides,significant positive correlations were found of MDA level to p22phox,p47phox and NF-?B in the renal tissue,?-lipoic acid seems to protect the diabetic kidney in this diabetic rat model via antioxidative effects.
