Association of expression of prepro-orexin and orexin receptors with hypothalamic-pituitary-adrenal axis in obese rats
- VernacularTitle:肥胖大鼠前增食欲素原及增食欲素受体基因表达与下丘脑-垂体-肾上腺轴有关
- Author:
Li-Bin LIU
;
Li-Ping LIAO
;
Zhou CHEN
;
Xiao-Hong LIU
;
- Publication Type:Journal Article
- Keywords:
Obesity;
Orexin;
Receptor,orexin;
Hypothalamo-pituitary-adrenal axis
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Expression of prepro-orexin gene in the hypothalamus was decreased in rats with dietary obesity,and has no correlation with serum corticosterone concentration.Expression of orexin receptor-2 in adrenal was increased in obese rats,and was positively correlated to expression of CRH mRNA and inversely correlated to serum corticosterene concentration.
