Free fatty acids regulate expression of adiponectin receptor gene in adipocytes
- VernacularTitle:游离脂肪酸调节脂肪细胞脂联素受体基因的表达
- Author:
Yu WEN
;
Hong-Wei WANG
;
Jing WU
;
Hui-Ling LU
;
Xiu-Fen HU
;
Zhi XIA
;
- Publication Type:Journal Article
- Keywords:
3T3-LI cells;
Fatty acids,non esterified;
Receptor,adiponectin
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
3T3-LI preadipocytes were induced to differentiate and 3T3-L1 adipocyte or preadipocytes were incubated with oleate or palmitate overnight.RT-PCR was used to measure adiponectin receptor(AdipoR)1 and AdipoR2 mRNA levels.The results showed that the AdipoRl and AdipoR2 expressions were differentiation- dependent.Oleate only suppressed AdipoR mRNA expression in preadipocyte but not in adipocyte.However,high concentration of palmitate reduced AdipoR mRNA expression in both 3T3-LI preadipocyte and adipocyte.
