Alterations of protein phosphatase-2A in peripheral lymphocytes in mild cognition impairment and Alzheimer's disease
- VernacularTitle:轻度认知障碍及阿尔茨海默病患者外周血淋巴细胞中蛋白磷酸酯酶-2A的改变
- Author:
Zhong-Sen QU
;
Yong-Bo ZHAO
;
Xing-Bin WANG
;
Wen-Wen LIU
;
Qiao-Shu WANG
;
- Publication Type:Journal Article
- Keywords:
Cognition impairment;
Alzheimer disease;
Lymphocyte;
Phosphoprotein phosphatase
- From:
Chinese Journal of Neurology
2005;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the alterations of protein phosphatase-2A (PP-2A) in lymphocytes in mild cognition impairment (MCI) and Alzheimer's disease (AD).Methods The activity PP-2A of was measured by ~(32)p liquid seintillography for incorporated radioactivity in control group(n=11) , the MCI group(n=11),and the AD group(n=11).The expression of PP-2A was determined by Western blot.Results In the control group,the activity of PP-2A (1.01?0.09) and the expression of PP-2A (0.96?0.07) were high while in the MCI group,the activity of PP-2A (0.71?0.12) and the expression of PP-2A (0.80?0.05) were decreased (both P
