Inhibitory effects of stachyose on hyperacute rejection in pig-to-human heart xenotransplantation
- VernacularTitle:水苏糖对模拟异种心脏移植超急性排斥反应的抑制作用
- Author:
Bo LIU
;
Ke-Wei NI
;
Bing ZHOU
;
- Publication Type:Journal Article
- Keywords:
Graft rejection;
Stachyose;
Transplantation,heterologous;
Pig
- From:
Chinese Journal of Organ Transplantation
2005;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the inhibitory effects of stachyose on the hyperacute rejection in pig-to-human heart xenotransplantation.Methods A pig-to-human xenogeneic heart transplantation model was established based on an in vitro free heart blood perfusion system.The pig hearts were di- vided into two groups:group A(pig hearts treated with human blood perfusion as control)and group B(pig hearts treated with human blood plus stachyose perfusion).After perfusion for 1h,the heart xenografts were examined for deposit of lgG and IgM by immunohistochemistry and pathological analy sis.Results The mean survival time of perfusion hearts in groups A and B was(9.5?2.5)min and (46.8?8.1)min respectively(P
