Blockade of CD28-B7 and CD40-CD40 ligand interactions induces long-term heart allograft survival and donor-specific tolerance in mice
- VernacularTitle:联合阻断CD28/B7与CD40/CD40L共刺激通路诱导抗原特异性免疫耐受
- Author:
Mei GU
;
Xiao-Feng JIANG
;
Bim-Xing GUAN
;
- Publication Type:Journal Article
- Keywords:
Antigens,CD80;
Antigens,CD40;
Heart transplantation;
Immune tolerance;
Mice
- From:
Chinese Journal of Organ Transplantation
2005;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
50 days),whereas third party skin grafts were vigorously rejected.Conclusion Blockade of CD28-B7 and CD40-CD40 ligand interactions resulted in long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation without chronic rejection.
