Preventive effects of soybean isoflavones on chronic allograft nephropathy in rats
- VernacularTitle:大豆异黄酮对大鼠慢性移植肾肾病的防治作用
- Author:
Qiang LIU
;
Li PENG
;
Yan-Ling SHI
;
- Publication Type:Journal Article
- Keywords:
Isoflavones;
chronic allograft nephropathy;
Kidney transplantion;
Soybean
- From:
Chinese Journal of Organ Transplantation
2005;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify whether soybean isoflavones plays a role in the prevention of chronicallograft nephropathy(CAN)in rats.Methods Forty-five male Lewis rats as receptors were randomly divided into 3 groups,receiving a diet with protein from high isoflavone soy protein fraction (HIS),low isoflavone soy protein fraction(LIS)or casein(CAS)starting one week before renal transplants from fisher donors,and continuing throughout the study.Serial serum and urine samples were collected at the beginning of the study,and at 4th,12th and 24th week.All rats were killed and the grafts were harvested in the 24th week.The functional and histopathogical changes of renal grafts were evaluated.Results In HIS group,arteria caudilis systolic blood pressure(SBP)value,24 h uri- nary protein(Upro)and serum creatitine(Cr)concentrations were significantly lower than those in LIS and CAS groups(all P
