Conversion from calcineurin inhibitor to sirolimus for renal function deterioration in kidney allograft recipients
- VernacularTitle:移植肾功能减退受者使用西罗莫司替代钙调磷酸酶抑制剂的转换治疗
- Author:
Kai YAO
;
Guo-Hai SHI
;
Xiang-Hui WANG
;
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Sirolimus;
Immunosuppression
- From:
Chinese Journal of Organ Transplantation
2005;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
20% increase in serum creatinine over the last 6 months or progression to the range of 176-308?mol/L.Patients underwent abrupt cessation of cyelosporine and sirolimus maintenance at 1-2 rag/day after administration of 4-6 mg as first loading dose.Concomitant immunosuppression remained unchanged during conversion.Results Targeted sirolimus level was 4-8 ng/mL.Serum creatinine was dropped from pre-conversion level of(242.15?73.04)?mol/L to(188.32?58.96)?mol/L and (173.36?58.08)?mol/L at 3rd and 6th month respectively(P
