Expression of cyclooxypenase-2 and the relation between cyclooxypenase-2 and CD_(105)in osteosarcoma
- VernacularTitle:骨肉瘤组织环氧合酶-2、CD_(105)表达与预后
- Author:
Zhen OUYANG
;
Shuanke WANG
;
Cuifang WANG
;
Xuewen KANG
;
Hongzhang GUO
;
- Publication Type:Journal Article
- Keywords:
Cyclooxypenase-2;
Microvessl density;
Osteosarcoma;
Prognosis
- From:
Cancer Research and Clinic
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of cyclooxypenase-2(COX-2),prognosis of patients and the correlation between COX-2 and CD_(105)in osteosarcoma.Methods The expression of COX-2 and CD_(105)in human osteosarcoma was detected with immunohistochemistry.Then to count the microvessl density (MVD)were marked with CD_(105),The prognosis of the patients with osteosarcoma was analyzed by Cox multi- variate survival analysis.Results The positive rate of COX-2 expression was 77.5 %,The expression of COX-2 was positively correlated with surgical grade and metastasis of osteosarcoma;There were significant difference between surgical grade Ⅰ and Ⅱ b、grade Ⅰ and Ⅲ(P0.05);Metastatic cases had higher MVD than those without metastasis(P
